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Target
Nuclear receptor ROR-gamma
Ligand
BDBM363747
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4.26±n/a nM
Citation
 Khairatkar-Joshi, N; Kulkarni, A; Shah, DM; Bhosale, VM; Lodhiya, BJ; Thiraviam, AM; Marathe, M; Hadambar, AA Treatment of respiratory disorders using ROR-gamma inhibitors US Patent  US9855229 Publication Date 1/2/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM363747
Synonyms:
US9855229, Compound 1
Type:
Small organic molecule
Emp. Form.:
C28H31F2N3O4S
Mol. Mass.:
543.625
SMILES:
CCN1C2C=CC(NC(=O)Cc3ccc(cc3)S(=O)(=O)CC)=CC2N=C1C(C)(C)Oc1ccc(F)cc1F |c:4,22,26|
Structure:
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