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Target
Nuclear receptor ROR-gamma
Ligand
BDBM363753
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.615±n/a nM
Citation
 Khairatkar-Joshi, N; Kulkarni, A; Shah, DM; Bhosale, VM; Lodhiya, BJ; Thiraviam, AM; Marathe, M; Hadambar, AA Treatment of respiratory disorders using ROR-gamma inhibitors US Patent  US9855229 Publication Date 1/2/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM363753
Synonyms:
US9855229, Compound 7
Type:
Small organic molecule
Emp. Form.:
C22H13Cl2F2NO3
Mol. Mass.:
448.246
SMILES:
OC(=O)c1ccc(N2C=C(C3C=CC=C(F)C23)C(=O)c2c(Cl)cccc2Cl)c(F)c1 |c:8,11,t:13|
Structure:
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