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Target
Nuclear receptor ROR-gamma
Ligand
BDBM363754
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.98±n/a nM
Citation
 Khairatkar-Joshi, N; Kulkarni, A; Shah, DM; Bhosale, VM; Lodhiya, BJ; Thiraviam, AM; Marathe, M; Hadambar, AA Treatment of respiratory disorders using ROR-gamma inhibitors US Patent  US9855229 Publication Date 1/2/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM363754
Synonyms:
US9855229, Compound 8
Type:
Small organic molecule
Emp. Form.:
C23H18ClN3O3
Mol. Mass.:
419.86
SMILES:
OC(=O)c1ccc(cc1)N1N=C(C2C=CC=NC12)C(=O)c1c(Cl)cccc1C1CC1 |c:11,14,16|
Structure:
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