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Target
D(1A) dopamine receptor
Ligand
BDBM364218
Substrate
n/a
Meas. Tech.
cAMP HTRF Assay
Ki
5.50±n/a nM
Citation
 Gray, DL; Davoren, JE; Dounay, AB; Efremov, IV; Mente, SR; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US9856263 Publication Date 1/2/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM364218
Synonyms:
US9856263, 1 | US9856263, 2 | US9856263, 3
Type:
Small organic molecule
Emp. Form.:
C21H17N5O
Mol. Mass.:
355.3926
SMILES:
Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12 |(4,-6.93,;4,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;1.33,2.31,;,1.54,;-1.46,2.02,;-2.37,.77,;-1.46,-.48,;;4,-2.31,;5.33,-3.08,;5.33,-4.62,;6.67,-5.39,;8,-4.62,;8,-3.08,;9.34,-5.39,;9.34,-6.93,;8,-7.7,;7.68,-9.21,;6.15,-9.37,;5.52,-7.96,;6.67,-6.93,)|
Structure:
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