Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1
Ligand
BDBM365164
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
0.111±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US9867833 Publication Date 1/16/2018 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM365164
Synonyms:
4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyridin-2-amine | US10278975, Compound I-83 | US10517878, Compound I-83 | US10842799, I-83 | US11376260, Example I-83 | US9867833, Compound I-83
Type:
Small organic molecule
Emp. Form.:
C24H19ClFN7O
Mol. Mass.:
475.905
SMILES:
Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(F)c(Cl)c3)c3nnc(c1)n23
Structure:
Search PDB for entries with ligand similarity: