Reaction Details Report a problem with these data
Target
Interferon-induced, double-stranded RNA-activated protein kinase
Ligand
BDBM364984
Substrate
n/a
Meas. Tech.
PKR KinaseGlo Assay
IC50
167±n/a nM
Citation
 Boral, S; Malone, TC; Wang, S Pyridyl benzothiophenes as kinase inhibitors US Patent  US9868726 Publication Date 1/16/2018 
Target
Name:
Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms:
E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase
Type:
PROTEIN
Mol. Mass.:
62104.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467743
Residue:
551
Sequence:
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC
  
Inhibitor
Name:
BDBM364984
Synonyms:
6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]-5-{5-[({[2- fluoro-5- (trifluoromethyl)phenyl]amino} carbonyl)amino]-1- benzothien-2-yl}nicotinamide | US10633373, Example 6 | US10669265, Example 6 | US9868726, Example 6
Type:
Small organic molecule
Emp. Form.:
C24H19F4N5O3S2
Mol. Mass.:
565.563
SMILES:
CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Structure:
Search PDB for entries with ligand similarity: