Reaction Details Report a problem with these data
Target
Interleukin-17A
Ligand
BDBM247032
Substrate
n/a
Meas. Tech.
Human TH17 Cytokine Inhibition ELISA Assay
IC50
<10000±n/a nM
Citation
 Gaweco, A; Tilley, J; Blinn, J Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof US Patent  US9701663 Publication Date 7/11/2017 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM247032
Synonyms:
US9701663, 47 | rac.-cis-1-((-5-methyl-1-(phenylsulfonyl)pyrrolidin-3-yl)methyl)-5-(1H-pyrazol-4-yl)-1H-indole
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2S
Mol. Mass.:
420.527
SMILES:
C[C@@H]1CC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CN1S(=O)(=O)c1ccccc1 |r|
Structure:
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