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Target
Tyrosine-protein kinase SYK
Ligand
BDBM142598
Substrate
n/a
Meas. Tech.
Syk Enzyme Inhibition 1
IC50
42.0±n/a nM
Citation
Cariou, CA; Charron, CE; Fordyce, EA; Hamza, D; Fyfe, MC; Ito, K; King-Underwood, J; Murray, PJ; Onions, ST; Thom, SM; Watson, HT; Williams, JG Pyrazolyl-ureas as kinase inhibitors US Patent US9701670 Publication Date 7/11/2017
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM142598
Synonyms:
US10238658, Example Reference | US10813932, Reference Compound | US8933228, Ref 2 | US9242960, 1 | US9249125, Reference Compound | US9701670, Reference Compound | US9724347, Example Reference | US9993478, Example Reference
Type:
Small organic molecule
Emp. Form.:
C33H34N6O4
Mol. Mass.:
578.6609
SMILES:
COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1