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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368666
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368666
Synonyms:
US10227350, Compound 84
Type:
Small organic molecule
Emp. Form.:
C26H19ClF2N8
Mol. Mass.:
516.932
SMILES:
CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1 |(-7.02,-1.57,;-5.48,-1.57,;-4.71,-.24,;-3.17,-.24,;-2.69,-1.7,;-1.15,-1.7,;-.12,-2.85,;1.39,-2.53,;1.86,-1.06,;.83,.08,;-.67,-.24,;-1.92,.67,;-1.92,2.21,;-.59,2.98,;-.59,4.52,;-1.92,5.29,;-3.25,4.52,;-4.59,5.29,;-4.59,6.83,;-5.92,4.52,;-5.92,2.98,;-4.59,2.21,;-4.59,.67,;-3.25,2.98,;3.35,-.66,;3.75,.82,;5.24,1.22,;6.33,.13,;5.93,-1.35,;7.02,-2.44,;4.44,-1.75,;4.04,-3.24,;-.52,-4.33,;.39,-5.58,;-.52,-6.83,;-1.98,-6.35,;-1.98,-4.81,)|
Structure:
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