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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368702
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368702
Synonyms:
US10227350, Compound 117 | US10227350, Compound 118 | US10227350, Compound 160
Type:
Small organic molecule
Emp. Form.:
C24H15F3N8
Mol. Mass.:
472.4247
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(N)c1F)-c1nnc[nH]1 |(-5.33,.53,;-3.79,.53,;-3.31,-.93,;-1.77,-.93,;-.74,-2.08,;.76,-1.76,;1.24,-.29,;.21,.85,;-1.3,.53,;-2.54,1.44,;-2.54,2.98,;-1.21,3.75,;-1.21,5.29,;-2.54,6.06,;-3.88,5.29,;-5.21,6.06,;-6.55,5.29,;-7.88,6.06,;-6.55,3.75,;-5.21,2.98,;-5.21,1.44,;-3.88,3.75,;2.73,.11,;3.12,1.59,;4.61,1.99,;5.7,.9,;5.3,-.58,;6.39,-1.67,;3.81,-.98,;3.42,-2.47,;-1.14,-3.56,;-.24,-4.81,;-1.14,-6.06,;-2.61,-5.58,;-2.61,-4.04,)|
Structure:
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