Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615672
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615672
Synonyms:
US20230271954, Compound 3A | trans-6-chloro-4-((4-(cyclopropyl(phenyl)amino) cyclohexyl)amino)-1-methyl-2-oxo-1,2-dihydro-1,5- naphthyridine-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C25H26ClN5O
Mol. Mass.:
447.96
SMILES:
Cn1c2ccc(Cl)nc2c(N[C@H]2CC[C@@H](CC2)N(C2CC2)c2ccccc2)c(C#N)c1=O |r,wU:11.11,wD:14.18,(-1.44,6.93,;-1.44,5.39,;-2.77,4.62,;-4.1,5.39,;-5.44,4.62,;-5.44,3.08,;-6.77,2.31,;-4.1,2.31,;-2.77,3.08,;-1.44,2.31,;-1.44,.77,;-.1,,;1.23,.77,;2.56,,;2.56,-1.54,;1.23,-2.31,;-.1,-1.54,;3.9,-2.31,;5.23,-1.54,;6.77,-1.54,;6,-.21,;3.9,-3.85,;2.56,-4.62,;2.56,-6.16,;3.9,-6.93,;5.23,-6.16,;5.23,-4.62,;-.1,3.08,;1.23,2.31,;2.56,1.54,;-.1,4.62,;1.23,5.39,)|
Structure:
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