Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615711
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615711
Synonyms:
US20230271954, Compound 10 | cis-6-chloro-4-((4-(cyclobutyl(4-fluorophenyl)amino) cyclohexyl)(methyl)amino)-1-methyl-2-oxo-1,2- dihydro-1,5-naphthyridine-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C27H29ClFN5O
Mol. Mass.:
494.003
SMILES:
CN(C1CC[C@@H](CC1)N(C1CCC1)c1ccc(F)cc1)c1c(C#N)c(=O)n(C)c2ccc(Cl)nc12 |r,wU:5.8,(-1.61,-4.24,;-1.61,-2.7,;-.28,-1.93,;1.06,-2.7,;2.39,-1.93,;2.39,-.39,;1.06,.38,;-.28,-.39,;3.72,.38,;5.06,-.39,;5.46,-1.87,;6.94,-1.47,;6.55,.01,;3.72,1.92,;5.06,2.69,;5.06,4.23,;3.72,5,;3.72,6.54,;2.39,4.23,;2.39,2.69,;-2.94,-1.93,;-2.94,-.39,;-1.61,.38,;-.28,1.15,;-4.28,.38,;-4.28,1.92,;-5.61,-.39,;-6.94,.38,;-5.61,-1.93,;-6.94,-2.7,;-6.94,-4.24,;-5.61,-5.01,;-5.61,-6.54,;-4.28,-4.24,;-4.28,-2.7,)|
Structure:
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