Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615752
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615752
Synonyms:
US20230271954, Compound 51 | cis-6-chloro-4-((4-(cyclopropyl(4-fluorophenyl) amino)cyclohexyl)(methyl)amino)-1-methyl-2-oxo- 1,2-dihydro-1,5-naphthyridine-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H27ClFN5O
Mol. Mass.:
479.977
SMILES:
CN(C1CC[C@@H](CC1)N(C1CC1)c1ccc(F)cc1)c1c(C#N)c(=O)n(C)c2ccc(Cl)nc12 |r,wU:5.8,(-1.44,-4.24,;-1.44,-2.7,;-.1,-1.93,;1.23,-2.7,;2.56,-1.93,;2.56,-.39,;1.23,.38,;-.1,-.39,;3.9,.38,;5.23,-.39,;6.77,-.39,;6,-1.72,;3.9,1.92,;5.23,2.69,;5.23,4.23,;3.9,5,;3.9,6.54,;2.56,4.23,;2.56,2.69,;-2.77,-1.93,;-2.77,-.39,;-1.44,.38,;-.1,1.15,;-4.1,.38,;-4.1,1.92,;-5.44,-.39,;-6.77,.38,;-5.44,-1.93,;-6.77,-2.7,;-6.77,-4.24,;-5.44,-5.01,;-5.44,-6.54,;-4.1,-4.24,;-4.1,-2.7,)|
Structure:
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