Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615756
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615756
Synonyms:
US20230271954, Compound 55 | cis-8-((4-((4-fluorophenyl)((tetrahydrofuran-3-yl) methyl)amino)cyclohexyl)(methyl)amino)-5-methyl- 6-oxo-5,6-dihydro-1,5-naphthyridine-2,7- dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C29H31FN6O2
Mol. Mass.:
514.5938
SMILES:
CN(C1CC[C@@H](CC1)N(CC1CCOC1)c1ccc(F)cc1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:5.8,(-2.55,-3.47,;-2.55,-1.93,;-1.22,-1.16,;.11,-1.93,;1.45,-1.16,;1.45,.38,;.11,1.15,;-1.22,.38,;2.78,1.15,;4.12,.38,;5.45,1.15,;6.86,.53,;7.89,1.67,;7.12,3.01,;5.61,2.69,;2.78,2.69,;4.12,3.46,;4.12,5,;2.78,5.77,;2.78,7.31,;1.45,5,;1.45,3.46,;-3.89,-1.16,;-3.89,.38,;-2.55,1.15,;-1.22,1.92,;-5.22,1.15,;-5.22,2.69,;-6.55,.38,;-7.89,1.15,;-6.55,-1.16,;-7.89,-1.93,;-7.89,-3.47,;-6.55,-4.29,;-5.22,-3.47,;-5.22,-1.93,;-6.55,-5.83,;-6.55,-7.37,)|
Structure:
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