Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615758
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615758
Synonyms:
US20230271954, Compound 57 | US20230271954, Compound 58 | cis-8-((4-((4-fluorophenyl)((tetrahydro-2H-pyran-3- yl)methyl)amino)cyclohexyl)(methyl)amino)-5- methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7- dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C30H33FN6O2
Mol. Mass.:
528.6204
SMILES:
CN([C@H]1CCC(CC1)N(CC1CCCOC1)c1ccc(F)cc1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:2.1,(-2.67,-3.47,;-2.67,-1.93,;-1.33,-1.15,;-1.33,.38,;,1.15,;1.33,.38,;1.33,-1.15,;,-1.93,;2.67,1.15,;4,.38,;5.33,1.15,;5.33,2.69,;6.67,3.47,;8,2.69,;8,1.15,;6.67,.38,;2.67,2.69,;1.33,3.47,;1.33,5,;2.67,5.78,;2.67,7.31,;4,5,;4,3.47,;-4,-1.15,;-3.94,.46,;-2.61,1.24,;-1.29,2.03,;-5.33,1.15,;-5.33,2.69,;-6.67,.38,;-8,1.15,;-6.67,-1.15,;-8,-1.92,;-8,-3.46,;-6.67,-4.23,;-5.33,-3.47,;-5.33,-1.93,;-6.67,-5.77,;-6.67,-7.31,)|
Structure:
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