Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615786
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615786
Synonyms:
US20230271954, Compound 85 | trans-6-chloro-4-4-((cyclopropylmethyl)(3,4- difluoro-5-methoxyphenyl)amino)cyclohexyl) (methyl)amino)-1-methyl-2-oxo-1,2-dihydro-1,5- naphthyridine-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C28H30ClF2N5O2
Mol. Mass.:
542.02
SMILES:
COc1cc(cc(F)c1F)N(CC1CC1)C1CC[C@@H](CC1)N(C)c1c(C#N)c(=O)n(C)c2ccc(Cl)nc12 |r,wU:18.23,(.56,6.16,;.56,4.62,;1.9,3.85,;1.9,2.31,;3.23,1.54,;4.56,2.31,;4.56,3.85,;5.9,4.62,;3.23,4.62,;3.23,6.16,;3.23,,;4.56,-.77,;5.9,,;7.44,,;6.67,1.33,;1.9,-.77,;.56,,;-.77,-.77,;-.77,-2.31,;.56,-3.08,;1.9,-2.31,;-2.1,-3.08,;-2.1,-4.62,;-3.44,-2.31,;-4.73,-3.17,;-4.71,-4.71,;-4.69,-6.25,;-6.1,-2.31,;-7.44,-3.08,;-6.1,-.77,;-7.44,,;-4.77,,;-4.77,1.54,;-3.44,2.31,;-2.1,1.54,;-.77,2.31,;-2.1,,;-3.44,-.77,)|
Structure:
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