Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615792
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615792
Synonyms:
US20230271954, Compound 91 | cis-8-4-((cyclobutylmethyl)(4-fluoro-3- methylphenyl)amino)cyclohexyl)(methyl)amino)-5- methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7- dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C30H33FN6O
Mol. Mass.:
512.621
SMILES:
CN([C@H]1CCC(CC1)N(CC1CCC1)c1ccc(F)c(C)c1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:2.1,(-2.28,-4.62,;-2.28,-3.08,;-.94,-2.31,;-.94,-.77,;.39,,;1.72,-.77,;1.72,-2.31,;.39,-3.08,;3.06,,;4.39,-.77,;5.73,,;7.21,-.4,;7.61,1.09,;6.12,1.49,;3.06,1.54,;1.72,2.31,;1.72,3.85,;3.06,4.62,;3.06,6.16,;4.39,3.85,;5.73,4.62,;4.39,2.31,;-3.61,-2.31,;-4.9,-3.17,;-4.88,-4.71,;-4.86,-6.25,;-6.28,-2.31,;-7.61,-3.08,;-6.28,-.77,;-7.61,,;-4.94,,;-4.94,1.54,;-3.61,2.31,;-2.28,1.54,;-2.28,,;-3.61,-.77,;-.94,2.31,;.39,3.08,)|
Structure:
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