Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615798
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615798
Synonyms:
US20230271954, Compound 97 | cis-8-4-(benzo[d][1,3]dioxol-5-yl(cyclobutylmethyl) amino)cyclohexyl)(methyl)amino)-5-methyl-6-oxo- 5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C30H32N6O3
Mol. Mass.:
524.6135
SMILES:
CN([C@H]1CCC(CC1)N(CC1CCC1)c1ccc2OCOc2c1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:2.1,(-2.28,-4.68,;-2.28,-3.14,;-.94,-2.37,;-.94,-.83,;.39,-.06,;1.72,-.83,;1.72,-2.37,;.39,-3.14,;3.06,-.06,;4.39,-.83,;5.73,-.06,;7.21,-.46,;7.61,1.03,;6.12,1.42,;3.06,1.48,;1.72,2.25,;1.72,3.79,;3.06,4.56,;3.38,6.06,;4.91,6.22,;5.54,4.82,;4.39,3.79,;4.39,2.25,;-3.61,-2.37,;-4.9,-3.23,;-4.88,-4.77,;-4.86,-6.31,;-6.28,-2.37,;-7.61,-3.14,;-6.28,-.83,;-7.61,-.06,;-4.94,-.06,;-4.94,1.48,;-3.61,2.25,;-2.28,1.48,;-2.28,-.06,;-3.61,-.83,;-.94,2.25,;.39,3.02,)|
Structure:
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