Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615803
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615803
Synonyms:
US20230271954, Compound 102 | cis-8-4-((cyclopropylmethyl)(3,5-dimethoxyphenyl) amino)cyclohexyl)(methyl)amino)-5-methyl-6-oxo- 5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C30H34N6O3
Mol. Mass.:
526.6294
SMILES:
COc1cc(OC)cc(c1)N(CC1CC1)C1CC[C@@H](CC1)N(C)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:18.23,(-.77,4.62,;.56,5.39,;1.9,4.62,;3.23,5.39,;4.56,4.62,;5.9,5.39,;7.23,4.62,;4.56,3.08,;3.23,2.31,;1.9,3.08,;3.23,.77,;4.56,,;5.9,.77,;7.44,.77,;6.67,2.1,;1.9,,;.56,.77,;-.77,,;-.77,-1.54,;.56,-2.31,;1.9,-1.54,;-2.1,-2.31,;-2.1,-3.85,;-3.44,-1.54,;-4.73,-2.4,;-4.71,-3.94,;-4.69,-5.48,;-6.1,-1.54,;-7.44,-2.31,;-6.1,,;-7.44,.77,;-4.77,.77,;-4.77,2.31,;-3.44,3.08,;-2.1,2.31,;-2.1,.77,;-3.44,,;-.77,3.08,;.56,3.85,)|
Structure:
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