Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615833
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615833
Synonyms:
US20230271954, Compound 132 | trans-4-((-4-(benzo[d][1,3]dioxol-4- yl(cyclobutylmethyl)amino)cyclohexyl)(methyl) amino)-6-chloro-1-methyl-2-oxo-1,2-dihydro-1,5- naphthyridine-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C29H32ClN5O3
Mol. Mass.:
534.049
SMILES:
CN([C@H]1CC[C@@H](CC1)N(CC1CCC1)c1cccc2OCOc12)c1c(C#N)c(=O)n(C)c2ccc(Cl)nc12 |r,wU:5.8,wD:2.1,(1.07,4.37,;1.07,2.83,;-.27,2.06,;-1.6,2.83,;-2.93,2.06,;-2.93,.52,;-1.6,-.25,;-.27,.52,;-4.27,-.25,;-5.6,.52,;-5.6,2.06,;-6.69,3.15,;-5.6,4.24,;-4.51,3.15,;-4.27,-1.79,;-2.93,-2.56,;-2.93,-4.1,;-4.27,-4.87,;-5.6,-4.1,;-7.07,-4.57,;-7.97,-3.33,;-7.07,-2.08,;-5.6,-2.56,;2.4,2.06,;2.4,.52,;1.07,-.25,;-.27,-1.02,;3.73,-.25,;3.73,-1.79,;5.07,.52,;6.4,-.25,;5.07,2.06,;6.4,2.83,;6.4,4.37,;5.07,5.14,;5.07,6.68,;3.73,4.37,;3.73,2.83,)|
Structure:
Search PDB for entries with ligand similarity: