Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615842
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615842
Synonyms:
US20230271954, Compound 141 | trans-8-((-4-((cyclobutylmethyl)(6-fluoro-4- methylpyridin-3-yl)amino)cyclohexyl)(methyl) amino)-5-methyl-6-oxo-5,6-dihydro-1,5- naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C29H32FN7O
Mol. Mass.:
513.6091
SMILES:
Cc1cc(F)ncc1N(CC1CCC1)[C@H]1CC[C@H](CNc2c(C#N)c(=O)n(C)c3ccc(nc23)C#N)CC1 |r,wU:17.19,wD:14.15,(4,-14.63,;2.67,-13.86,;1.33,-14.63,;,-13.86,;-1.33,-14.63,;,-12.32,;1.33,-11.55,;2.67,-12.32,;4,-11.55,;5.33,-12.32,;6.67,-11.55,;7.07,-10.06,;8.55,-10.46,;8.16,-11.95,;4,-10.01,;5.33,-9.24,;5.33,-7.7,;4,-6.93,;4,-5.39,;2.67,-4.62,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-3.85,;4,-.77,;5.33,,;2.67,,;2.67,1.54,;1.33,-.77,;;-1.33,-.77,;-1.33,-2.31,;,-3.08,;1.33,-2.31,;-2.67,-3.08,;-4,-3.85,;2.67,-7.7,;2.67,-9.24,)|
Structure:
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