Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615844
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615844
Synonyms:
US20230271954, Compound 143 | cis-8-((-4-(benzo[d][1,3]dioxol-5-yl(((R)-tetrahydro- 2H-pyran-3-yl)methyl)amino)cyclohexyl)(methyl) amino)-5-methyl-6-oxo-5,6-dihydro-1,5- naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C31H34N6O4
Mol. Mass.:
554.6395
SMILES:
CN(C1CC[C@@H](CC1)N(C[C@H]1CCCOC1)c1ccc2OCOc2c1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:5.8,wD:10.10,(-2.67,-3.53,;-2.67,-1.99,;-1.33,-1.22,;,-1.99,;1.33,-1.22,;1.33,.32,;,1.09,;-1.33,.32,;2.67,1.09,;4,.32,;5.33,1.09,;6.67,.32,;8,1.09,;8,2.63,;6.67,3.4,;5.33,2.63,;2.67,2.63,;1.33,3.4,;1.33,4.94,;2.67,5.71,;2.99,7.22,;4.52,7.38,;5.15,5.97,;4,4.94,;4,3.4,;-4,-1.22,;-4,.32,;-2.67,1.09,;-1.33,1.86,;-5.33,1.09,;-5.33,2.63,;-6.67,.32,;-8,1.09,;-6.67,-1.22,;-8,-1.99,;-8,-3.53,;-6.67,-4.35,;-5.33,-3.53,;-5.33,-1.99,;-6.67,-5.89,;-6.67,-7.43,)|
Structure:
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