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Target
Tyrosine-protein kinase SYK
Ligand
BDBM254893
Substrate
n/a
Meas. Tech.
SYK kinase assay
IC50
139±n/a nM
Citation
 Chen, S; Hermann, JC; Le, NT; Lucas, MC; Padilla, F Thienopyrimidine compounds US Patent  US9701691 Publication Date 7/11/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM254893
Synonyms:
2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-thieno[3,2- d]pyrimidine-7-carboxylic acid (6-ethyl-pyridin-2- yl)-amide | US9701691, 1
Type:
Small organic molecule
Emp. Form.:
C14H11ClN4OS
Mol. Mass.:
318.781
SMILES:
CCc1cccc(NC(=O)c2csc3cnc(Cl)nc23)n1
Structure:
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