Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM255750
Substrate
n/a
Meas. Tech.
SYK kinase assay
IC50
79.0±n/a nM
Citation
Chen, S; Hermann, JC; Le, NT; Lucas, MC; Padilla, F Thienopyrimidine compounds US Patent US9701691 Publication Date 7/11/2017
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM255750
Synonyms:
2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-thieno[3,2- d]pyrimidine-7-carboxylic acid (6-[1,2,3]triazol-2-yl- pyridin-2-yl)-amide | US9701691, 5
Type:
Small organic molecule
Emp. Form.:
C19H19N9O2S
Mol. Mass.:
437.478
SMILES:
N[C@H]1COCC[C@H]1Nc1ncc2scc(C(=O)Nc3cccc(n3)-n3nccn3)c2n1 |r|