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Target
Tyrosine-protein kinase SYK
Ligand
BDBM255754
Substrate
n/a
Meas. Tech.
SYK kinase assay
IC50
41.0±n/a nM
Citation
 Chen, S; Hermann, JC; Le, NT; Lucas, MC; Padilla, F Thienopyrimidine compounds US Patent  US9701691 Publication Date 7/11/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM255754
Synonyms:
2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d]pyrimidine- 7-carboxylic acid (1H- benzoimidazol-2-yl)- amide | US9701691, 9
Type:
Small organic molecule
Emp. Form.:
C20H21N7OS
Mol. Mass.:
407.492
SMILES:
N[C@H]1CCCC[C@H]1Nc1ncc2scc(C(=O)Nc3nc4ccccc4[nH]3)c2n1 |r|
Structure:
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