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Target
Tyrosine-protein kinase SYK
Ligand
BDBM255759
Substrate
n/a
Meas. Tech.
SYK kinase assay
IC50
2462±n/a nM
Citation
Chen, S; Hermann, JC; Le, NT; Lucas, MC; Padilla, F Thienopyrimidine compounds US Patent US9701691 Publication Date 7/11/2017
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM255759
Synonyms:
2-(2-Methylamino- ethylamino)-thieno[3,2- d]pyrimidine-7-carboxylic acid (1-methyl-1H- benzoimidazol-4-yl)- amide hydrochloride | US9701691, 14
Type:
Small organic molecule
Emp. Form.:
C18H19N7OS
Mol. Mass.:
381.455
SMILES:
CNCCNc1ncc2scc(C(=O)Nc3cccc4n(C)cnc34)c2n1