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Target
Tyrosine-protein kinase SYK
Ligand
BDBM255760
Substrate
n/a
Meas. Tech.
SYK kinase assay
IC50
5977±n/a nM
Citation
 Chen, S; Hermann, JC; Le, NT; Lucas, MC; Padilla, F Thienopyrimidine compounds US Patent  US9701691 Publication Date 7/11/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM255760
Synonyms:
2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d]pyrimidine- 7-carboxylic acid (6- fluoro-1-methyl-1H- indazol-3-yl)-amide trifluoroacetate | US9701691, 15
Type:
Small organic molecule
Emp. Form.:
C23H23F4N7O3S
Mol. Mass.:
553.532
SMILES:
OC(=O)C(F)(F)F.Cn1nc(NC(=O)c2csc3cnc(N[C@@H]4CCCC[C@@H]4N)nc23)c2ccc(F)cc12 |r|
Structure:
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