Reaction Details Report a problem with these data
Target
Peptide deformylase
Ligand
BDBM21683
Substrate
PDF substrate peptide
Meas. Tech.
PDF Inhibition Assay
pH
7.6±n/a
Temperature
298.15±n/a K
IC50
250±30 nM
Km
2600000±n/a nM
kcat
152±n/a 1/sec
Citation
Smith, KJ; Petit, CM; Aubart, K; Smyth, M; McManus, E; Jones, J; Fosberry, A; Lewis, C; Lonetto, M; Christensen, SB Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species. Protein Sci 12:349-60 (2003) [PubMed] Article
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1
Type:
Enzyme
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus
Description:
P68825
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
Inhibitor
Name:
BDBM21683
Synonyms:
N-hydroxy-N-(3-phenylpropyl)formamide | SB-485345
Type:
Small organic molecule
Emp. Form.:
C10H13NO2
Mol. Mass.:
179.2157
SMILES:
ON(CCCc1ccccc1)C=O
Substrate
Name:
PDF substrate peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1718.01
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
FRMYLMETALASER