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Target
PRKC apoptosis WT1 regulator protein
Ligand
BDBM370620
Substrate
n/a
Meas. Tech.
FLIPR assay
IC50
930±n/a nM
Citation
 Ruediger, EH; Deon, DH; Gagnon, M; Posy, SL Benzothiazole and benzothiophene compounds US Patent  US10238638 Publication Date 3/26/2019 
Target
Name:
PRKC apoptosis WT1 regulator protein
Synonyms:
PAR4 | PAWR | PAWR_HUMAN | Par-4 | Prostate apoptosis response 4 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36562.04
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
340
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
  
Inhibitor
Name:
BDBM370620
Synonyms:
US10238638, Example 67
Type:
Small organic molecule
Emp. Form.:
C31H30N6O4S3
Mol. Mass.:
646.803
SMILES:
COc1cc(OCc2csc(n2)-c2ccc(cc2)C(=O)N2CCC(C)(CO)CC2)c2sc(nc2c1)-c1cn2nc(C)sc2n1
Structure:
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