Reaction Details Report a problem with these data
Target
Legumain
Ligand
BDBM22133
Substrate
BDBM22115
Meas. Tech.
AE Enzyme Inhibition Assay
pH
6.8±n/a
Temperature
295.15±n/a K
IC50
>2000±n/a nM
Citation
Götz, MG; James, KE; Hansell, E; Dvorák, J; Seshaadri, A; Sojka, D; Kopácek, P; McKerrow, JH; Caffrey, CR; Powers, JC Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens. J Med Chem 51:2816-32 (2008) [PubMed] Article
Target
Name:
Legumain
Synonyms:
Asparaginyl Endopeptidase (AE)
Type:
Enzyme
Mol. Mass.:
49047.79
Organism:
Schistosoma mansoni
Description:
Q9NFY9
Residue:
429
Sequence:
MMLFSLFLISILHILLVKCQLDTNYEVSDETVSDNNKWAVLVAGSNGYPNYRHQADVCHAYHVLRSKGIKPEHIITMMYDDIAYNLMNPFPGKLFNDYNHKDWYEGVVIDYRGKKVNSKTFLKVLKGDKSAGGKVLKSGKNDDVFIYFTDHGAPGLIAFPDDELYAKQFMSTLKYLHSHKRYSKLVIYIEACESGSMFQRILPSNLSIYATTAASPTESSYGTFCDDPTITTCLADLYSYDWIVDSQTHHLTQRTLDQQYKEVKRETNLSHVQRYGDTRMGKLHVSEFQGSRDKSSTENDEPPMKPRHSIASRDIPLHTLHRQIMMTNNAEDKSFLMQILGLKLKRRDLIEDTMKLIVKVMNNEEIPNTKATIDQTLDCTESVYEQFKSKCFTLQQAPEVGGHFSTLYNYCADGYTAETINEAIIKICG
Inhibitor
Name:
BDBM22133
Synonyms:
aza-peptide Michael acceptor, 7e | benzyl N-[(1S)-1-{[(1S)-1-[N'-(carbamoylmethyl)-N'-[(2E)-3-(furan-2-yl)prop-2-enoyl]hydrazinecarbonyl]ethyl]carbamoyl}ethyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C23H27N5O7
Mol. Mass.:
485.4898
SMILES:
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)C=Cc1ccco1 |r,w:28.28|