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Target
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Ligand
BDBM202696
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity
IC50
0.376±n/a nM
Citation
 Aversa, RJ; Barsanti, PA; Burger, MT; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, GA; Pan, Y; Polyakov, VR; Ramurthy, S; Rico, AC; Setti, LQ; Smith, A; Subramanian, S; Taft, BR; Tanner, HR; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US10245267 Publication Date 4/2/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:
C-Raf TR | P04049 (aa 1-324) | RAF | RAF proto-oncogene serine/threonine-protein kinase (aa 1-324) | RAF1 | RAF1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42815.85
Organism:
Homo sapiens (Human)
Description:
P04049 (aa 1-324)
Residue:
384
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP
  
Inhibitor
Name:
BDBM202696
Synonyms:
US10245267, Example 43 | US10709712, Example 42 | US9242969, 42 | US9694016, 42
Type:
Small organic molecule
Emp. Form.:
C26H25F3N4O2
Mol. Mass.:
482.4975
SMILES:
CC(=C)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Structure:
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