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Target
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Ligand
BDBM202845
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity
IC50
0.455±n/a nM
Citation
 Aversa, RJ; Barsanti, PA; Burger, MT; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, GA; Pan, Y; Polyakov, VR; Ramurthy, S; Rico, AC; Setti, LQ; Smith, A; Subramanian, S; Taft, BR; Tanner, HR; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US10245267 Publication Date 4/2/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:
C-Raf TR | P04049 (aa 1-324) | RAF | RAF proto-oncogene serine/threonine-protein kinase (aa 1-324) | RAF1 | RAF1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42815.85
Organism:
Homo sapiens (Human)
Description:
P04049 (aa 1-324)
Residue:
384
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP
  
Inhibitor
Name:
BDBM202845
Synonyms:
US10245267, Example 198 | US10709712, Example 198 | US9242969, 198 | US9694016, 198
Type:
Small organic molecule
Emp. Form.:
C22H20F3N3O2S
Mol. Mass.:
447.473
SMILES:
Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(s1)N1CCOCC1
Structure:
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