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Target
G protein-coupled receptor kinase 6
Ligand
BDBM34883
Substrate
n/a
Meas. Tech.
TBD
IC50
7050±n/a nM
Citation
 Stewart, AK; Plekhov, A; Greenhouse, R Inhibiting G protein coupled receptor 6 kinase polypeptides US Patent  US10252984 Publication Date 4/9/2019 
Target
Name:
G protein-coupled receptor kinase 6
Synonyms:
GPRK6 | GRK6 | GRK6_HUMAN
Type:
PROTEIN
Mol. Mass.:
66001.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_793895
Residue:
576
Sequence:
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
  
Inhibitor
Name:
BDBM34883
Synonyms:
5-[2-keto-2-(2,3,4-trihydroxyphenyl)ethyl]furan-2-carboxylic acid ethyl ester | 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-2-furancarboxylic acid ethyl ester | MLS000690569 | SMR000298833 | US10252984, Table 2.1 | cid_854609 | ethyl 5-[2-oxidanylidene-2-[2,3,4-tris(oxidanyl)phenyl]ethyl]furan-2-carboxylate | ethyl 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-2-furoate | ethyl 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]furan-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H14O7
Mol. Mass.:
306.2675
SMILES:
CCOC(=O)c1ccc(CC(=O)c2ccc(O)c(O)c2O)o1
Structure:
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