Reaction Details Report a problem with these data
Target
G protein-coupled receptor kinase 6
Ligand
BDBM89185
Substrate
n/a
Meas. Tech.
TBD
IC50
18750±n/a nM
Citation
 Stewart, AK; Plekhov, A; Greenhouse, R Inhibiting G protein coupled receptor 6 kinase polypeptides US Patent  US10252984 Publication Date 4/9/2019 
Target
Name:
G protein-coupled receptor kinase 6
Synonyms:
GPRK6 | GRK6 | GRK6_HUMAN
Type:
PROTEIN
Mol. Mass.:
66001.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_793895
Residue:
576
Sequence:
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
  
Inhibitor
Name:
BDBM89185
Synonyms:
3-Amino-5-(2-diethylamino-ethyl)-5H-pyrido[4,3-b]indole-4-carbonitrile | 3-amino-5-[2-(diethylamino)ethyl]-4-pyrido[4,3-b]indolecarbonitrile | 3-amino-5-[2-(diethylamino)ethyl]pyrid[4,3-b]indole-4-carbonitrile | 3-amino-5-[2-(diethylamino)ethyl]pyrido[4,3-b]indole-4-carbonitrile | 3-azanyl-5-[2-(diethylamino)ethyl]pyrido[4,3-b]indole-4-carbonitrile | MLS000554093 | SMR000146410 | US10252984, Table 2.28 | cid_946898
Type:
Small organic molecule
Emp. Form.:
C18H21N5
Mol. Mass.:
307.3928
SMILES:
CCN(CC)CCn1c2ccccc2c2cnc(N)c(C#N)c12
Structure:
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