Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM377212
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
<100±n/a nM
Citation
 Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US10265307 Publication Date 4/23/2019 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM377212
Synonyms:
US10265307, Example 53-2 | US10517858, Example 53 (Diastereoisomer 2) | US10828290, Example 53 (Diastereoisomer 2)
Type:
Small organic molecule
Emp. Form.:
C24H26F2N6O3S
Mol. Mass.:
516.563
SMILES:
COc1ccc(F)c(-c2nc(C(=O)Nc3cnc4[C@H](O)CCc4c3N3CCC[C@H](N)C3)c(N)s2)c1F |r|
Structure:
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