Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase BTK
Ligand
BDBM377389
Substrate
n/a
Meas. Tech.
Human Recombinant Btk Enzyme Assay
IC50
0.075±n/a nM
Citation
 Ahmad, S; Batt, DG; Liu, Q; Macor, JE; Tino, JA; Watterson, SH; Nair, SK; Maishal, TK Carbazole derivatives US Patent  US10266491 Publication Date 4/23/2019 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM377389
Synonyms:
US10266491, Example 57 | US10266491, Example 58 | US10676434, Example 58 | US11053197, Example 58
Type:
Small organic molecule
Emp. Form.:
C26H27ClN4O3
Mol. Mass.:
478.971
SMILES:
CN(C)C(=O)C1CCc2c(C1)[nH]c1c(cc(Cl)c(-c3cccc(NC(=O)C=C)c3C)c21)C(N)=O |(-5.38,-3.39,;-6.46,-2.3,;-7.95,-2.7,;-6.07,-.81,;-7.15,.28,;-4.58,-.41,;-3.67,-1.66,;-2.14,-1.5,;-1.51,-.09,;-2.42,1.15,;-3.95,.99,;-1.51,2.4,;-.05,1.93,;1.28,2.69,;2.62,1.93,;2.62,.38,;3.95,-.38,;1.28,-.38,;1.28,-1.93,;-.05,-2.69,;-.05,-4.23,;1.28,-5,;2.62,-4.23,;3.95,-5,;5.28,-4.23,;5.28,-2.69,;6.62,-5,;7.95,-4.23,;2.62,-2.69,;3.95,-1.93,;-.05,.38,;1.28,4.23,;2.62,5,;-.05,5,)|
Structure:
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