Target

Ligand

Substrate

Meas. Tech.

Akt Inhibition Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Hartnett, JC; Barnett, SF; Bilodeau, MT; Defeo-Jones, D; Hartman, GD; Huber, HE; Jones, RE; Kral, AM; Robinson, RG; Wu, Z Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors. Bioorg Med Chem Lett 18:2194-7 (2008) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM24895

Synonyms:

1-[1-({4-[3-phenyl-5-(pyrimidin-2-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 2,3,5-trisubstituted pyridine, 13c

Type:

Small organic molecule

Emp. Form.:

C32H29N9

Mol. Mass.:

539.633

SMILES:

Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ncccn2)CC1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

biotinylated Akt peptide substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

1734.89

Organism:

n/a

Description:

n/a

Residue:

17

Sequence:

ITINGGRARTSSFAEPG