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Target
D(3) dopamine receptor
Ligand
BDBM382334
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
2.14±n/a nM
Citation
 Micheli, F; Cremonesi, S; Semeraro, T; Tarsi, L Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators US Patent  US10273244 Publication Date 4/30/2019 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM382334
Synonyms:
US10273244, Example 219
Type:
Small organic molecule
Emp. Form.:
C25H34F3N5OS
Mol. Mass.:
509.631
SMILES:
Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |r,w:27.31,31.35,wU:9.8,13.12,(3.57,7.24,;3.97,8.73,;3.07,9.97,;1.58,9.57,;.49,10.66,;-1,10.26,;-2.09,11.35,;-3.57,10.95,;-4.48,12.2,;-5.94,11.72,;-7.41,12.2,;-8.31,10.95,;-7.41,9.71,;-5.94,10.18,;-4.48,9.71,;-7.81,8.22,;-9.29,7.82,;-9.69,6.34,;-8.62,5.19,;-7.12,5.64,;-6.72,7.13,;-9.02,3.71,;-9.41,2.22,;-10.5,4.1,;-7.53,3.31,;3.97,11.22,;5.44,10.74,;5.44,9.2,;6.77,8.43,;6.77,6.89,;8.1,6.12,;9.44,6.89,;10.77,6.12,;9.44,8.43,;8.1,9.2,)|
Structure:
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