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Target
Sterol O-acyltransferase 2
Ligand
BDBM383182
Substrate
n/a
Meas. Tech.
Inhibitory Effect on ACAT2 Activity
IC50
245±n/a nM
Citation
 Nan, F; Li, B; Zhan, Y; Zhang, X; Xiong, Y; Hu, X; Zhang, Y Tricyclic analogues, preparation method and uses thereof US Patent  US10278962 Publication Date 5/7/2019 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM383182
Synonyms:
US10278962, Compound 16
Type:
Small organic molecule
Emp. Form.:
C27H31NO10
Mol. Mass.:
529.5357
SMILES:
CC(=O)OCC(C)(OC(C)=O)[C@@H]1C[C@H](OC(C)=O)[C@@]2(C)Oc3cc(oc(=O)c3[C@H](O)[C@@H]2C1)-c1cccnc1 |r,w:5.4|
Structure:
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