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Target
Lysine-specific demethylase 2B
Ligand
BDBM383541
Substrate
n/a
Meas. Tech.
KDM2B TR-FRET Assay
IC50
26.0±n/a nM
Citation
 Albrecht, BK; Cote, A; Gehling, V; Hsiao-Wei Tsui, V; Kiefer, JR; Liang, J; Magnuson, S; Nasveschuk, CG; Pastor, R; Romero, FA; Taylor, AM; Zhang, B Therapeutic compounds and uses thereof US Patent  US10280149 Publication Date 5/7/2019 
Target
Name:
Lysine-specific demethylase 2B
Synonyms:
AA 1-650 | CXXC2 | FBL10 | FBXL10 | Homo sapiens lysine demethylase 2B (KDM2B) | JHDM1B | KDM2B | KDM2B_HUMAN | Lysine-specific demethylase 2B | Lysine-specific demethylase 2B (KDM2B) | NDY1 | NM_032590 | PCCX2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
152658.35
Organism:
Homo sapiens (Human)
Description:
Q8NHM5
Residue:
1336
Sequence:
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
  
Inhibitor
Name:
BDBM383541
Synonyms:
(6-methoxy-5-methyl-2-naphthyl)-(1-propyl-3-piperidyl)methanone | US10280149, Example 50
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
CCCN1CCCC(C1)C(=O)c1ccc2c(C)c(OC)ccc2c1
Structure:
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