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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384569
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
7.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384569
Synonyms:
4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)piperidin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-3 | US9932350, 3-4 | US9932350, 3-5
Type:
Small organic molecule
Emp. Form.:
C21H24F3N5
Mol. Mass.:
403.444
SMILES:
FC(F)(F)C1CCCN(C1)C1CCC(CC1)Nc1ncnc2ccc(cc12)C#N |(5.78,-4.67,;5,-6,;5.78,-7.34,;6.54,-6,;3.47,-6,;2.69,-7.34,;1.15,-7.34,;.38,-6,;1.15,-4.67,;2.69,-4.67,;.38,-3.33,;1.15,-2,;.38,-.67,;-1.15,-.67,;-1.93,-2,;-1.15,-3.33,;-1.93,.67,;-3.47,.67,;-4.23,-.67,;-5.78,-.67,;-6.54,.67,;-5.78,2,;-6.54,3.33,;-5.78,4.67,;-4.23,4.67,;-3.47,3.33,;-4.23,2,;-3.47,6,;-2.69,7.34,)|
Structure:
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