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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384590
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384590
Synonyms:
4-({trans-4-[(4aS,7aS or 4aR,7aR)- hexahydrocyclopenta[b] [1,4]oxazin-4(4aH)- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-24
Type:
Small organic molecule
Emp. Form.:
C22H27N5O
Mol. Mass.:
377.4827
SMILES:
N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOC4CCCC34)c2c1 |r,wU:11.10,wD:14.17,(-1.99,7.34,;-2.76,6,;-3.53,4.67,;-5.07,4.67,;-5.84,3.33,;-5.07,2,;-5.84,.67,;-5.07,-.67,;-3.53,-.67,;-2.76,.67,;-1.22,.67,;-.45,-.67,;1.09,-.67,;1.86,-2,;1.09,-3.33,;-.45,-3.33,;-1.22,-2,;1.86,-4.67,;1.09,-6,;1.86,-7.34,;3.4,-7.34,;4.17,-6,;5.68,-5.68,;5.84,-4.15,;4.43,-3.52,;3.4,-4.67,;-3.53,2,;-2.76,3.33,)|
Structure:
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