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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384615
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
6.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384615
Synonyms:
US9932350, 3-45 | tert-butyl 4-{trans-4-[(6- cyanoquinazolin-4- yl)amino]cyclohexyl} piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H32N6O2
Mol. Mass.:
436.5499
SMILES:
CC(C)(C)OC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:13.13,wD:16.20,(6.93,-8,;5.39,-8,;4.62,-9.34,;6.16,-6.67,;4.62,-6.67,;3.08,-6.67,;2.31,-8,;2.31,-5.33,;.77,-5.33,;,-4,;.77,-2.67,;2.31,-2.67,;3.08,-4,;,-1.33,;-1.54,-1.33,;-2.31,,;-1.54,1.33,;,1.33,;.77,,;-2.31,2.67,;-3.85,2.67,;-4.62,1.33,;-6.16,1.33,;-6.93,2.67,;-6.16,4,;-6.93,5.33,;-6.16,6.67,;-4.62,6.67,;-3.85,5.33,;-4.62,4,;-3.85,8,;-3.08,9.34,)|
Structure:
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