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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384637
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
14.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384637
Synonyms:
4-[(trans-4-{4-[(3- methyloxetan-3- yl)carbonyl]piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile | US9932350, 6-9
Type:
Small organic molecule
Emp. Form.:
C24H30N6O2
Mol. Mass.:
434.534
SMILES:
CC1(COC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:16.21,wD:13.14,(5.8,-8.67,;5.03,-7.34,;4.63,-5.85,;6.12,-5.45,;6.52,-6.94,;3.49,-7.34,;2.72,-8.67,;2.72,-6,;1.18,-6,;.41,-4.67,;1.18,-3.33,;2.72,-3.33,;3.49,-4.67,;.41,-2,;1.18,-.67,;.41,.67,;-1.13,.67,;-1.9,-.67,;-1.13,-2,;-1.9,2,;-3.44,2,;-4.21,.67,;-5.75,.67,;-6.52,2,;-5.75,3.33,;-6.52,4.67,;-5.75,6,;-4.21,6,;-3.44,4.67,;-4.21,3.33,;-3.44,7.34,;-2.67,8.67,)|
Structure:
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