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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384639
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384639
Synonyms:
4-[(trans-4-{4-[(2S)- tetrahydrofuran-2- ylcarbonyl]piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile | US9932350, 6-11
Type:
Small organic molecule
Emp. Form.:
C24H30N6O2
Mol. Mass.:
434.534
SMILES:
O=C([C@@H]1CCCO1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:16.21,2.1,wD:13.14,(2.28,-8.67,;3.05,-7.34,;4.59,-7.34,;5.5,-8.58,;6.96,-8.11,;6.96,-6.57,;5.5,-6.09,;2.28,-6,;.74,-6,;-.03,-4.67,;.74,-3.33,;2.28,-3.33,;3.05,-4.67,;-.03,-2,;.74,-.67,;-.03,.67,;-1.57,.67,;-2.34,-.67,;-1.57,-2,;-2.34,2,;-3.88,2,;-4.65,.67,;-6.19,.67,;-6.96,2,;-6.19,3.33,;-6.96,4.67,;-6.19,6,;-4.65,6,;-3.88,4.67,;-4.65,3.33,;-3.88,7.34,;-3.11,8.67,)|
Structure:
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