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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384642
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
13.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384642
Synonyms:
4-[(trans-4-{4-[(2,2- difluorocyclopropyl) carbonyl]piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile | US9932350, 6-14
Type:
Small organic molecule
Emp. Form.:
C23H26F2N6O
Mol. Mass.:
440.4889
SMILES:
FC1(F)CC1C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:16.21,wD:13.14,(7.21,-7.72,;5.67,-7.72,;4.9,-9.05,;5.67,-6.18,;4.34,-6.95,;2.8,-6.95,;2.03,-8.28,;2.03,-5.62,;.49,-5.62,;-.28,-4.28,;.49,-2.95,;2.03,-2.95,;2.8,-4.28,;-.28,-1.62,;.49,-.28,;-.28,1.05,;-1.82,1.05,;-2.59,-.28,;-1.82,-1.62,;-2.59,2.39,;-4.13,2.39,;-4.9,1.05,;-6.44,1.05,;-7.21,2.39,;-6.44,3.72,;-7.21,5.05,;-6.44,6.39,;-4.9,6.39,;-4.13,5.05,;-4.9,3.72,;-4.13,7.72,;-3.36,9.05,)|
Structure:
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