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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM570323
Substrate
n/a
Meas. Tech.
cAMP Assays
EC50
0.003±n/a nM
Citation
 Meng, Q; Lei, H; Zhang, H; Lin, X; Jennings, A Heterocyclic GLP-1 agonists US Patent  US11897851 Publication Date 2/13/2024 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM570323
Synonyms:
US11897851, Compound 214
Type:
Small organic molecule
Emp. Form.:
C29H32ClFN6O
Mol. Mass.:
535.055
SMILES:
CCn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)ncc1C=C
Structure:
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