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Target
Prolyl hydroxylase EGLN2
Ligand
BDBM385722
Substrate
n/a
Meas. Tech.
PHD1 Enzyme Assay
IC50
47.0±n/a nM
Citation
 Ahmed, S; Barker, G; Canning, H; Davenport, R; Harrison, D; Jenkins, K; Livermore, D; Wright, S; Kinsella, N Compounds US Patent  US10287286 Publication Date 5/14/2019 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM385722
Synonyms:
2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amino}- [1,2,4]triazolo[1,5- a]pyridin-5- yl)benzonitrile | US10287286, Example 127
Type:
Small organic molecule
Emp. Form.:
C18H16FN5O
Mol. Mass.:
337.3509
SMILES:
CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1
Structure:
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