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Target
Prolyl hydroxylase EGLN2
Ligand
BDBM385794
Substrate
n/a
Meas. Tech.
PHD1 Enzyme Assay
IC50
53.0±n/a nM
Citation
 Ahmed, S; Barker, G; Canning, H; Davenport, R; Harrison, D; Jenkins, K; Livermore, D; Wright, S; Kinsella, N Compounds US Patent  US10287286 Publication Date 5/14/2019 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM385794
Synonyms:
1-methylpiperidin-4-yl N-[5- (4-cyano-3 -fluorophenyl)- [1,2,4]triazolo[1,5-a]pyridin- 7-yl]carbamate | US10287286, Example 197
Type:
Small organic molecule
Emp. Form.:
C20H19FN5NaO2
Mol. Mass.:
403.3853
SMILES:
C[Na]1CCC(CC1)OC(=O)Nc1cc(-c2ccc(C#N)c(F)c2)n2ncnc2c1 |(6.52,,;5.19,-.77,;5.19,-2.31,;3.85,-3.08,;2.52,-2.31,;2.52,-.77,;3.85,,;1.18,-3.08,;1.18,-4.62,;2.52,-5.39,;-.15,-5.39,;-1.48,-4.62,;-1.48,-3.08,;-2.82,-2.31,;-2.82,-.77,;-4.15,,;-4.15,1.54,;-2.82,2.37,;-2.82,3.91,;-2.82,5.45,;-1.48,1.54,;-.15,2.31,;-1.48,,;-4.15,-3.08,;-5.61,-2.6,;-6.52,-3.85,;-5.61,-5.1,;-4.15,-4.62,;-2.82,-5.39,)|
Structure:
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