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Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM391835
Substrate
n/a
Meas. Tech.
Biological Assays
Ki
37500±n/a nM
Citation
 Pache, L; Chanda, SK; Vamos, MD; Cosford, ND; Teriete, P; Marlett, J; Diaz, A; Young, JA Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy US Patent  US10300074 Publication Date 5/28/2019 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIR3 (aa 241-356) | BIR3 domain | BIRC4 | IAP3 | XIAP | XIAP Bir3 | XIAP_HUMAN | amino acids 241-356 of XIAP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14548.06
Organism:
Homo sapiens (Human)
Description:
P98170[241-356]
Residue:
125
Sequence:
MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Inhibitor
Name:
BDBM391835
Synonyms:
US10300074, Compd 30 | US10300074, Compd 31 | US11111270, Compound 31
Type:
Small organic molecule
Emp. Form.:
C30H35N5O3
Mol. Mass.:
513.6306
SMILES:
CN[C@@H](C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 |r|
Structure:
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